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KMID : 0665420220370060503
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Korean Journal of Food Culture
2022 Volume.37 No. 6 p.503 ~ p.509
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Antiglycation and Protective Effect of Juglans regia L. in MGO-induced Renal cell Death
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Choi Ji-Won
Choi Sang-Yoon
Yoo Gui-Jae
Hur Jin-Young
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Abstract
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Methylglyoxal is a highly reactive precursor which forms advanced glycation end products (AGEs). AGEs andmethylglyoxal are known to induce various diseases such as diabetes, vascular disorders, Diabetes Mellitus (DM), andneuronal disorders. Juglans regia L is an important food commonly used worldwide, having nutritious components,including phenolic compounds. Since ancient times, Juglans regia L have been differently applied by various countries forhealth and in diverse diseases, including arthritis, asthma, skin disorders, cancer, and diabetes mellitus. However, the effectof diabetes-induced renal damage against AGEs remains unclear. This study evaluates the anti-glycation and renalprotective effects of ethanol extract of Juglans regia L against methylglyoxal-induced renal tubular epithelial cell death.
Exposure to methylglyoxal resulted in reduced cell viability in NRK-52E cells, but co-treatment with Juglans regia L extractssignificantly increased the cell viability. In addition, we examined the anti-glycation effect of Juglans regia L extracts.
Compared to the positive control aminoguanidine and Alagebrium, treatment with Juglans regia L extracts significantlyinhibited the formation of AGEs, collagen cross-linking, and breaking collagen cross-linking. Taken together, our resultsindicate that Juglans regia L is a potential therapeutic agent for regulating diabetic complications by exerting anti-glycationand renal protective activities.
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KEYWORD
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Juglans regia L, methylglyoxal, advanced glycation end products, anti-glycation, NRK-52E cells
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